Platelet Indices in Acute Myocardial Infarction - An Observational Study
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Abstract
Background: Platelet volume indices (PVI) such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) have been implicated in the pathogenesis and prognosis of acute coronary syndromes (ACS). This study aimed to evaluate the diagnostic and prognostic utility of PVI in ACS among the Kashmiri population. Methods: A prospective observational study was conducted at GMC Srinagar from October 2022 to April 2024, enrolling 570 ACS patients and 285 age- and sex-matched healthy controls. PVI were compared between cases and controls, as well as among ACS subtypes: STEMI, NSTEMI, and unstable angina. Prognostic value was assessed for in-hospital and 30-day mortality. Results: MPV, PDW, and PCT were significantly higher in ACS patients compared to controls (p<0.001 for all). STEMI patients had significantly higher MPV and PDW compared to NSTEMI and unstable angina groups. PCT did not differ significantly among ACS subtypes. Multivariate analysis identified age ≥60 years, STEMI presentation, and elevated PDW as independent predictors of 30-day mortality. Platelet count did not differ significantly between cases and controls or among ACS subtypes. Conclusion: Elevated MPV, PDW, and PCT are associated with ACS and can be measured easily through routine hematological analysis. PDW, in particular, has prognostic significance for short-term mortality. PVI offer a simple, cost-effective adjunct for early detection, risk stratification, and prognostication in ACS.
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Copyright (c) 2025 Dr Mustafa Bashir, Dr Tavseef Ahmad Tali, Ms Bilkees Ashraf, Dr Toufeeq Ahmed Teli, Dr Fiza Amin
This work is licensed under a Creative Commons Attribution 4.0 International License.
Creative Commons License All articles published in Annals of Medicine and Medical Sciences are licensed under a Creative Commons Attribution 4.0 International License.
Dr Mustafa Bashir, Department of Cardiology, Government Medical College Baramulla, J&K, India.
Department of Cardiology, Government Medical College Baramulla, J&K, India.
Dr Tavseef Ahmad Tali, Department of Radiation Oncology, Government Medical College Baramulla, J&K, India.
Department of Radiation Oncology, Government Medical College Baramulla, J&K, India.
Ms Bilkees Ashraf, Community Health Officer, Block Zachaldara Handwara Kupwara, J&K, India.
Community Health Officer, Block Zachaldara Handwara Kupwara, J&K, India.
Dr Toufeeq Ahmed Teli, Department of Gynaecology & Obstetrics, Government Medical College Udhampur, J&K, India.
Department of Gynaecology & Obstetrics, Government Medical College Udhampur, J&K, India.
Dr Fiza Amin, Department of Gynaecology & Obstetrics, Ramzaan Hospital Gogji Bagh, Srinagar, J&K, India.
Department of Gynaecology & Obstetrics, Ramzaan Hospital Gogji Bagh, Srinagar, J&K, India.
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