Our Experience at Tertiary Care Center: Intraoperative Use of Sterile Medical Grade Honey (MGH) Versus Sodium Hyaluronate Carboxymethylcellulose (Seprafilm TM) in Preventing Postoperative Craniofacial Pain Following Temporalis Fascia Harvesting
Authors
##plugins.themes.bootstrap3.article.sidebar##
##plugins.themes.bootstrap3.article.main##
Abstract
Aim: The study’s objective was to assess, evaluate and compare the efficacy of Intraoperative use of sterile Medical Grade Honey (MGH) and sodium hyaluronate carboxymethylcellulose (Seprafilm TM) in preventing postoperative craniofacial pain after temporalis fascia harvesting. Method: The study involved 120 adult patients aged 20-70 who underwent a postauricular incision to harvest temporalis fascia. Sixty patients received a seprafilm TM sheet (Group A) and the other sixty were given sterile Medical Grade honey (Group B). Quantitative data was recorded, and qualitative data was represented as percentages and frequencies. A p-value below 0.05 was considered statistically significant. Results: The study found no significant differences in temporal pain, tenderness, pain during mastication, and pain during lower jaw movement between groups A and B postoperatively across all follow-up visits at seventh and fifteenth postoperative days with the exception of thirtieth day and no significant issues were observed in either group three months after surgery, despite both groups’ VAS scores remaining below 4. Conclusion: There was no statistically significant difference between the two groups suggests that the success rates of the Group A (Seprafilm TM) and Group B (Sterile Medical Grade Honey) were about equal. Nonetheless, both groups’ success rates were marginally greater when our findings were contrasted with those of past studies.
##plugins.themes.bootstrap3.article.details##
Copyright (c) 2025 Dr Balaji Shankarrao Mane, Dr Rushali Madhukar Gavali
This work is licensed under a Creative Commons Attribution 4.0 International License.
Creative Commons License All articles published in Annals of Medicine and Medical Sciences are licensed under a Creative Commons Attribution 4.0 International License.
[1] House WF, Sheehy JL. Myringoplasty: use of ear canal skin compared with other techniques. Arch Otolaryngol 1961; 73: 407-15. [CrossRef]
[2] Parida PK, Nochikattil SK, Surianarayanan G, Saxena SK, Ganesan S. A comparative study of temporalis fascia graft and vein graft in myringoplasty. Ind J Otolaryngol Head Neck Surg 2013; 65: 569-74. [CrossRef]
[3] Singh BJ, Sengupta A, Das SK, Ghosh D, Basak B. A comparative study of different graft materials used in myringoplasty. Ind J Otolaryngol Head Neck Surg 2009; 61: 131-4. [CrossRef]
[4] Ahn JH, Shim MJ. The use of sodium hyaluronate-carboxymethylcellulose to prevent postoperative mastication pain from harvesting of temporalis fascia. Auris Nasus Larynx 2013; 40: 7-10. [CrossRef]
[5] Emre A, Akin M, Isikgonul I, Yuksel O, Anadol AZ, Cifter C. Comparison of Intraperitoneal honey and sodium hyaluronate-carboxymethylcellulose (SeprafilmTM) for the prevention of postoperative intra-abdominal adhesions. Clinics 2009; 64: 363-8. [CrossRef]
[6] Oncel M, Remzi FH, Senegore AJ, Connor JT, Fazio VW. Comparison of novel liquid (Adcon-P) sodium hyaluronate and carboxymethylcellulose membrane (Seprafilm) postsurgical adhesion formation in a murine model. Dis Colon Rectum. 2003;46:187-91.
[7] Beck DE. The role of Seprafilm bioresorbable membrane in adhesion Prevention. Eur J Surg Suppl. 1997;(577):49-55.
[8] Altuntas I, Tahran O, Delibas N. Seprafilm reduces adhesions to Polypropylene mesh and increases peritoneal hydroxyproline. Am Surg. 2002;68:759-61.
[9] Aysan E, Ayar E, Aren A, Cifter C. The role of intra-peritoneal honey Administration in preventing post-operative peritoneal adhesions. Eur J Obstet and Gynecol and Reprod Biol. 2002;104:152-5.
[10] Macrac WA. Chronic post-surgical pain: 10 years on. Br J Anaesth 2008; 101: 77-86. [CrossRef]
[11] Malhotra M, Varshney S, Malhotra R, Joshi P. Indian perspectives on graft Materials used for repair of tympanic membrane. J Clin Diagn Res 2017; 11: ME01-ME06. [CrossRef]
[12] Sheehy JL, Glasscock III ME. Tympanic membrane grafting with temporalis fascia. Arch Otolaryngol 1967; 86: 391-402. [CrossRef]
[13] Prasad S, Gupta V, Kumar A, Naik SM. Cartilage Tympanoplasty: Is it more Effective than temporalis fascia grafting for tympanoplasty? Otolaryngology Online Journal 2015; 5: 1-1.
[14] Majeed J, Ahamed N. Comparative study between temporalis fascia and Tragal perichondrium in myringoplasty. IOSR Journal of Dental and Medical Sciences 2016; 15: 64-72.
[15] Katz J, Seltzer Z. Transition from acute to chronic postsurgical pain: risk Factors and protective factors. Expert Rev Neurother 2009; 9: 723-44. [CrossRef]
[16] Ng M, Linthicum Jr FH. Long term effects of silastic sheeting in the middle ear. Laryngoscope 1992; 102: 1097-102. [CrossRef]
[17] Erguder BI, Kilicoglu SS, Namuslu M, Kilicoglu B, Devrim E, Kismet K, et al. Honey prevent hepatic damage induced by obstruction of the Common bile duct. World J Gastroenterol. 2008;14:3729-32.
[18] Calli C, Tugyan K, Oncel S, Pinar E, Demirtaşoglu F, Calli AO, et al. Effectiveness of Royal jelly on tympanic membrane perforations: an Experimental study. J Otolaryngol Head Neck Surg. 2008; 37: 179-84.
[19] Hermanns R, Mateescu C, Thrasyvoulou A, Tananaki C,Wagener FA, Cremers NA. Defining the standards for medical Grade honey. J Apicult Res. 2020;59(2):125-35.
[20] Leong AG, Herst PM, Harper JL. Indigenous New Zealand Honeys exhibit multiple anti-inflammatory activities. Innate Immun. 2012;18(3):459-66.