Correlation Between Vitamin D and Calcium Levels in Patients with Non-Small Cell Lung Cancer Among Sumatera Utara Population
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Abstract
Background: Lung cancer is a multifactorial disease caused by many factors, including genetics and environment. Vitamin D and calcium play a role in cancer. In lung cancer, vitamin D and calcium have been reported to play a role in inhibiting tumor proliferation and metastasis, promoting tumor differentiation and apoptosis, and contributing to immunity. This study aims to determine the correlation between vitamin D and calcium levels in non-small cell lung cancer (NSCLC) patients among North Sumatra population. Methods: This cross-sectional study involved 52 NSCLC patients from hospitals in North Sumatra, Indonesia between January and April 2023. Serum 25 hydroxyvitamin D and calcium levels were evaluated. Vitamin D levels were measured using manual ELISA kit (Elabscience, USA), while calcium levels were measured using immunoassay method. Results: The majority of subjects were men (84.6%), with ages ranging from 29 to 70 years with an average age of 55.3 years. Almost all subjects showed deficient levels of vitamin D and normal calcium levels. The frequency of vitamin D levels was 3.8% sufficiency, 17.3% insufficiency, and 78.8% deficiency, while the frequency of calcium levels was 51.9% normal, 5.8% hypercalcemia, and 42.3% hypocalcemia. The average vitamin D level was 15.27 ng/ml and calcium level was 8.72 mg/dl. The Spearman correlation test results showed a very weak positive and not significant correlation between levels of vitamin D and calcium in patients with NSCLC (r=0.05, p>0.05). Conclusions: There was no significant correlation between vitamin D and calcium levels in NSCLC patients in the North Sumatra population.
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Copyright (c) 2025 Dina Octafrida Marpaung, Noni Novisari Soeroso, Putri Chairani Eyanoer, Elisna Syahruddin, Dina Keumala Sari
This work is licensed under a Creative Commons Attribution 4.0 International License.
Creative Commons License All articles published in Annals of Medicine and Medical Sciences are licensed under a Creative Commons Attribution 4.0 International License.
Dina Octafrida Marpaung, Faculty of Medicine, HKBP Nommensen University, Medan, Indonesia.
Faculty of Medicine, HKBP Nommensen University, Medan, Indonesia.
Noni Novisari Soeroso, Thoracic Oncology Division, Department of Pulmonology & Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Prof. Dr. Chairuddin P. Lubis Universitas Sumatera Utara Hospital, Jl. Dr. Mansyur No. 5, Medan, 20155, Indonesia.
Thoracic Oncology Division, Department of Pulmonology & Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Prof. Dr. Chairuddin P. Lubis Universitas Sumatera Utara Hospital, Jl. Dr. Mansyur No. 5, Medan, 20155, Indonesia.
Putri Chairani Eyanoer, Department of Community Medicine, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No. 5, Medan, 20155, Indonesia.
Department of Community Medicine, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No. 5, Medan, 20155, Indonesia.
Elisna Syahruddin, Department of Pulmonology & Respiratory Medicine, Persahabatan Hospital, Faculty of Medicine Universitas Indonesia, Jl. Persahabatan Raya No. 1, Jakarta, 13230, Indonesia.
Department of Pulmonology & Respiratory Medicine, Persahabatan Hospital, Faculty of Medicine Universitas Indonesia, Jl. Persahabatan Raya No. 1, Jakarta, 13230, Indonesia.
Dina Keumala Sari, Department of Nutrition, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No. 5, Medan, 20155, Indonesia.
Department of Nutrition, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No. 5, Medan, 20155, Indonesia.
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