Noteworthy Effect of Hemoglobin on Short-Term Mortality and Extubation Time of Elderly Patients Undergoing OPCABG
Authors
##plugins.themes.bootstrap3.article.main##
Abstract
Objective: Interest in off pump technique has markedly expanded in recent years. It has been shown that peroperative complications and mortality rates are reduced with the off-pump coronary bypass grafting (OPCABG) technique, even in high risk elderly patient groups. This study aimed to evaluate the results of patients over the age of 65 who underwent OPCABG. Methods: This study included 116 patients aged 65 and over who underwent coronary artery bypass graft surgery (CABG). Patients’ datas were collected from digital database. Demographic and clinical data such as peroperative data, comorbidities, additional treatment requirements and discharge status of all patients were recorded. Results: The mean age of the patients was 67.97 ±3.40 years. The extubation time of the patients was 331.68 ±222.08 minutes. When the factors affecting the extubation time were evaluated, hemoglobin (p: 0.016) was found to be statistically significant. The mortality rate was found to be 5.17% (n:6). When survivors and non-survivors were compared, the differences in ejection fraction, extubation time, troponin and hemoglobin level were found to be statistically significant. Logistic regression analysis revealed statistical significance for ejection fraction (0.011), troponin (0.036), and hemoglobin level (0.036). The discrimination power of troponin value was determined to be more successful than other parameters (odds ratio 1.105, AUC: 0.755, p: 0.036). Conclusion: Our findings support that, when performed by an experienced surgical team, OPCABG can be safely and effectively utilized in patients above 65 years. Although hemoglobin was found to be effective on both extubation time and short-term mortality rate, troponin was found to be the most effective factor on mortality rate.
##plugins.themes.bootstrap3.article.details##
Copyright (c) 2025 Erdem Çetin, PhD, Müge Arıkan, PhD, Abdullah Yeşilkaya, PhD, Emre Meriç, PhD

This work is licensed under a Creative Commons Attribution 4.0 International License.
Creative Commons License All articles published in Annals of Medicine and Medical Sciences are licensed under a Creative Commons Attribution 4.0 International License.
Erdem Çetin, PhD, Department of Cardiovascular Surgery, Karabuk University Faculty of Medicine, Karabük, Turkey.
Department of Cardiovascular Surgery, Karabuk University Faculty of Medicine, Karabük, Turkey.
Müge Arıkan, PhD, Department of Anesthesiology and Reanimation, Karabuk University Faculty of Medicine, Karabük, Turkey.
Department of Anesthesiology and Reanimation, Karabuk University Faculty of Medicine, Karabük, Turkey.
Abdullah Yeşilkaya, PhD, Department of Anesthesiology and Reanimation, Karabuk University Faculty of Medicine, Karabük, Turkey.
Department of Anesthesiology and Reanimation, Karabuk University Faculty of Medicine, Karabük, Turkey.
Emre Meriç, PhD, Department of Anesthesiology and Reanimation, Karabuk University Faculty of Medicine, Karabük, Turkey.
Department of Anesthesiology and Reanimation, Karabuk University Faculty of Medicine, Karabük, Turkey.
[1] Raja SG, Dreyfus GD. Off-pump coronary artery bypass surgery: to do or not to do? Current best available evidence. J Cardiothorac Vasc Anesth 2004; 18(4):486–505. DOI: 10.1053/j.jvca.2004.05.010
[2] Shroyer AL, Grover FL, Hattler B, Collins JF, McDonald GO, Kozora E, et al. On-pump versus off-pump coronary-artery bypass surgery. N Engl J Med 2009; 361(19):1827–37. DOI:10.1056/NEJMoa0902905
[3] Sheikhy A, Fallahzadeh A, Forouzannia K, Pashang M, Tajdini M, Momtahen S, et al. Off-pump versus on-pump coronary artery bypass graft surgery outcomes in patients with severe left ventricle dysfunction: inverse probability weighted study. BMC Cardiovasc Disord 2022; 22(1):488. DOI: 10.1186/s12872-022-02895-0
[4] Zhu ZG, Xiong W, Ding JL, Chen J, Li Y, Zhou JL, et al. Comparison of outcomes between off-pump versus on-pump coronary artery bypass surgery in elderly patients: a meta-analysis. Braz J Med Biol Res 2017; 50(3):5711. DOI: 10.1590/1414-431X20165711
[5] Panesar SS, Athanasiou T, Nair S, Rao C, Jones C, Nicolaou M, et al. Early outcomes in the elderly: a meta-analysis of 4921 patients undergoing coronary artery bypass grafting—comparison between off-pump and on-pump techniques. Heart 2006; 92(12):1808–16. DOI: 10.1136/hrt.2006.088450
[6] Cetin E, Can T, Unal CS, Keskin A, Kubat E, et al. OPCAB surgery with an alternative retraction method: a single-centre experience. Cardiovasc J Afr 2020; 31(1):16–20. DOI: 10.5830/CVJA-2019-038
[7] Karabdic IH, Straus S, Granov N, Hadzimehmedagic A, Berberovic B, Kabil E, et al. Off pump versus on pump coronary artery bypass grafting: short-term outcomes. Acta Inform Med. 2023; 31(2):107–10. DOI: 10.5455/aim.2023.31.107-110
[8] Wang C, Jiang Y, Wang Q, Wang D, Jiang X, Dong N, et al. Off-pump versus on-pump coronary artery bypass grafting in elderly patients at 30 days: a propensity score matching study. Postgrad Med J. 2024; 100(1184):414–20.DOI: 10.1093/postmj/qgad120
[9] Seabra VF, Alobaidi S, Balk EM, Poon AH, Jaber BL. Off-pump coronary artery bypass surgery and acute kidney injury: a meta-analysis of randomized controlled trials. Clin J Am Soc Nephrol. 2010; 5(10):1734-44. DOI: 10.2215/CJN.02800310
[10] Yuksel A, Yolgosteren A, Kan II, Cayir MC, Velioglu Y, Yalcin M, et al. A comparison of early clinical outcomes of off-pump and on-pump coronary artery bypass grafting surgery in elderly patients. Acta Chir Belg 2018; 118(2):99–104. DOI: 10.1080/00015458.2017.1383087
[11] Diegeler A, Börgermann J, Kappert U, Breuer M, Böning A, Ursulescu A, et al. Off-pump versus on-pump coronary-artery bypass grafting in elderly patients. N Engl J Med 2013; 368(13):1189–98. DOI: 10.1056/NEJMoa1211666
[12] Kitamura H, Tamaki M, Kawaguchi Y, Okawa Y, et al. Results of off-pump coronary artery bypass grafting with off-pump first strategy in octogenarian. J Card Surg 2021; 36(12):4611–6. DOI: 10.1111/jocs.16055
[13] Talas Z, Kanko M, Yavuz Ş, Omay O, Barış Ö, Arıkan AA, et al. Coronary bypass with beating heart technique; how to do it and our results. Kocaeli Med J 2023; 12(1):89–98. DOI: 10.5505/ktd.2023.00947
[14] Demir A, Pepeşengül E, Aydınlı B, Tezcan B, Eke H, Taşoğlu İ, et al. Cardiac surgery and anesthesia in an elderly and very elderly patient population: a retrospective study. Turk Gogus Kalp Damar Cerrahisi Derg 2011; 19(3):377–83. DOI: 10.5606/tgkdc.dergisi.2011.048
[15] Hallward G, Balani N, McCorkell S, Roxburgh J, Cornelius V. The Relationship Between Preoperative Hemoglobin Concentration, Use of Hospital Resources, and Outcomes in Cardiac Surgery. J Cardiothorac Vasc Anesth 2016; 30(4):901-8. DOI: 10.1053/j.jvca.2016.02.004
[16] Padmanabhan H, Siau K, Curtis J, Ng A, Menon S, Luckraz H, Brookes MJ. Preoperative Anemia and Outcomes in Cardiovascular Surgery: Systematic Review and Meta-Analysis. Ann Thorac Surg 2019; 108(6):1840-1848. DOI: 10.1016/j.athoracsur.2019.04.108
[17] Paparella D, Guida P, Scrascia G, Fanelli V, Contini M, Zaccaria S, Labriola G, Carbone C, Mastro F, Mazzei V. On-pump versus off-pump coronary artery bypass surgery in patients with preoperative anemia. J Thorac Cardiovasc Surg. 2015; 149(4):1018-26.e1. DOI: 10.1016/j.jtcvs.2014.12.049
[18] Straus S, Karabdic IH, Grabovica S, Hadzimehmedagic A, Djedovic M, Kabil E, et al. How important impact of low level of hematocrit can be on outcome in patients undergoing off pump coronary artery bypass surgery? Acta Inform Med. 2023; 31(2):102–6. DOI: 10.5455/aim.2023.31.107-110
[19] Herrmann J, Haude M, Lerman A, Schulz R, Volbracht L, Ge J, et al. Abnormal coronary flow velocity reserve after coronary intervention is associated with cardiac marker elevation. Circulation. 2001; 103(19):2339–45. DOI: 10.1161/01.cir.103.19.2339
[20] Matetzky S, Sharir T, Domingo M, Noc M, Chyu KY, Kaul S, et al. Elevated troponin I level on admission is associated with adverse outcome of primary angioplasty in acute myocardial infarction. Circulation. 2000; 102(14):1611–6. DOI: 10.1161/01.cir.102.14.1611