Diagnostic Performance of SARC-F and SARC-CalF in Screening for Sarcopenia in Postmenopausal Women
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Abstract
Background: Sarcopenia is a progressive loss of muscle strength and mass, highly prevalent among postmenopausal women. Early identification is critical, yet challenging in low-resource settings. This study evaluates and compares the diagnostic performance of SARC-F and SARC-CalF screening tools against EWGSOP2 criteria. Methods: A cross-sectional observational study was conducted on 370 postmenopausal women at Upper India Sugar Exchange Maternity Hospital, GSVM Medical College, Kanpur. Participants were evaluated using the SARC-F and SARC-CalF tools. Probable sarcopenia was confirmed using European working group on sarcopenia in older people 2 (EWGSOP2) cutoff (handgrip strength <16 kg). Sensitivity, specificity, Positive predictive Value, Negative Predictive Value, ROC-AUC, and diagnostic accuracy were calculated. Results: The prevalence of probable sarcopenia was 78.6%. SARC-F demonstrated sensitivity of 91.4% and specificity of 22.8%, while SARC-CalF showed significantly better sensitivity (99.3%) and specificity (100%). The Area Under Curve (AUC) for SARC-CalF was 0.980 (p<0.001). SARC-CalF had a Kappa agreement of 0.89 with the reference standard. Conclusion: SARC-CalF is a simple, accurate, and superior screening tool for sarcopenia in postmenopausal women. It should be adopted in both clinical and community-based screening protocols, especially in settings with limited access to advanced diagnostic modalities.
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Copyright (c) 2025 Dr. Saumya Rathore, Dr. Renu Gupta, Dr. Garima Gupta, Dr. Shaily Agarwal, Dr. Neena Gupta, Dr. Bandana Sharma
This work is licensed under a Creative Commons Attribution 4.0 International License.
Creative Commons License All articles published in Annals of Medicine and Medical Sciences are licensed under a Creative Commons Attribution 4.0 International License.
Dr. Saumya Rathore, Junior Resident, Department of Obstetrics & Gynaecology, GSVM Medical College, Kanpur, UP-208002 India.
Junior Resident, Department of Obstetrics & Gynaecology, GSVM Medical College, Kanpur, UP-208002 India.
Dr. Renu Gupta, Professor & Head Department of Obstetrics & Gynaecology, GSVM Medical College, Kanpur, UP-208002, India.
Professor & Head Department of Obstetrics & Gynaecology, GSVM Medical College, Kanpur, UP-208002, India.
Dr. Garima Gupta, Associate Professor, Department of Obstetrics & Gynaecology, GSVM Medical College, Kanpur, UP-208002, India.
Associate Professor, Department of Obstetrics & Gynaecology, GSVM Medical College, Kanpur, UP-208002, India.
Dr. Shaily Agarwal, Professor Department of Obstetrics & Gynaecology GSVM Medical College, Kanpur, UP-208002, India.
Professor Department of Obstetrics & Gynaecology GSVM Medical College, Kanpur, UP-208002, India.
Dr. Neena Gupta, Professor Department of Obstetrics & Gynaecology GSVM Medical College, Kanpur, UP-208002, India.
Professor Department of Obstetrics & Gynaecology GSVM Medical College, Kanpur, UP-208002, India.
Dr. Bandana Sharma, Professor Department of Obstetrics & Gynaecology GSVM Medical College, Kanpur, UP-208002, India.
Professor Department of Obstetrics & Gynaecology GSVM Medical College, Kanpur, UP-208002, India.
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