Prognostic Significance of Pretreatment Derived Hematological Markers and Serum Biochemical Parameters on the Overall Survival Rate in Individuals Diagnosed with Cervical Cancer Undergoing Curative Surgery
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Abstract
Objectives: This study aims to evaluate the prognostic value of pretreatment hematological and biochemical markers, including serum albumin, globulin, and alkaline phosphatase, on overall survival in cervical cancer patients who have undergone curative surgery. Materials and Methods: This retrospective cohort study was conducted at Malabar Cancer Centre, Kerala, analyzing data from cervical cancer patients in FIGO stage 1, who underwent surgery between January 2018 and February 2024. Key hematological and biochemical parameters were evaluated, and Kaplan-Meier analysis was performed to assess overall survival, with statistical significance set at p < 0.05. Results: The study analyzed the overall survival of 35 cervical cancer patients in relation to hematological indices such as LMR, NLR, PLR, MPVP and ALBALKP, along with the impact of co-morbidities and FIGO staging. Statistical analysis revealed no significant differences in survival outcomes across different LMR, NLR, PLR, MPVP and ALBALKP groups (p > 0.05). Additionally, FIGO staging showed that most cases were diagnosed in early invasive stages, and co-morbidities like diabetes and hypertension were common among patients. Conclusion: Tumor stage and co-morbid conditions significantly influenced survival markers LMR, NLR, PLR, MPVP, and ALBALKP showed no statistically significant association, highlighting the need for further research with larger cohorts to confirm their prognostic value.
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Copyright (c) 2026 Edakkadath Raghavan Sindhu, Keloth Erakodan Greeshma, Nandhini Devi, Mohandoss Murugesan, Kalpita Shringapure, DSA Karthickeyan
This work is licensed under a Creative Commons Attribution 4.0 International License.
Creative Commons License All articles published in Annals of Medicine and Medical Sciences are licensed under a Creative Commons Attribution 4.0 International License.
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