Diagnostic Accuracy of Magnetic Resonance Imaging in Assessing Myometrial Invasion in Endometrial Carcinoma: A Retrospective Single Centre Study
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Abstract
Background: Endometrial carcinoma is the most common gynecologic malignancy in developed nations. Accurate preoperative assessment of myometrial invasion is critical for staging and guiding surgical management. This study aimed to evaluate the diagnostic accuracy of 1.5 Tesla plain magnetic resonance imaging (MRI) in determining the depth of myometrial invasion compared with postoperative histopathology. Materials and Methods: A retrospective analysis was conducted on 189 patients with histologically confirmed endometrial carcinoma who underwent preoperative 1.5 T plain MRI using T1- and T2-weighted sequences. MRI findings were correlated with histopathological staging, and diagnostic indices, including sensitivity, specificity, predictive values, and area under the curve (AUC), were calculated across FIGO stages. Results: The mean patient age was 56.3 years, predominantly postmenopausal. MRI accuracy for detecting myometrial invasion was 85.8 % for Stage IA, 63.8 % for Stage IB, and 66.6 % for Stage II disease. Overall, MRI demonstrated 27.8 % sensitivity, 81.8 % specificity, 71.4 % PPV, and 40.9 % NPV, with an AUC of 0.562. Conclusion: Plain 1.5 T MRI showed moderate diagnostic accuracy with high specificity for early-stage endometrial carcinoma but limited sensitivity for advanced invasion. The study underscores MRI’s role as a practical preoperative tool, particularly in resource-limited settings lacking contrast or diffusion-weighted imaging.
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Copyright (c) 2025 S. Subbiah, J. Sakthi Usha Devi, S. Karnan Srinivas, S. Dorian Hanniel Terrence, Sasikala Kathiresan, Emil Phinehas Mariantony
This work is licensed under a Creative Commons Attribution 4.0 International License.
Creative Commons License All articles published in Annals of Medicine and Medical Sciences are licensed under a Creative Commons Attribution 4.0 International License.
S. Subbiah, Professor and HOD, Department of Surgical Oncology, Govt. Arignar Anna Memorial Cancer Hospital and Research Institute, Karapettai, Kanchipuram, Tamil Nadu, India
Professor and HOD, Department of Surgical Oncology, Govt. Arignar Anna Memorial Cancer Hospital and Research Institute, Karapettai, Kanchipuram, Tamil Nadu, India
J. Sakthi Usha Devi, Associate Professor, Department of Surgical Oncology, Kalaignar Centenary Super-Speciality Hospital, Guindy, Chennai, Tamil Nadu, India.
Associate Professor, Department of Surgical Oncology, Kalaignar Centenary Super-Speciality Hospital, Guindy, Chennai, Tamil Nadu, India.
S. Karnan Srinivas, Assistant Professor, Department of Surgical Oncology, Govt. Arignar Anna Memorial Cancer Hospital and Research Institute, Karapettai, Kanchipuram, Tamil Nadu, India.
Assistant Professor, Department of Surgical Oncology, Govt. Arignar Anna Memorial Cancer Hospital and Research Institute, Karapettai, Kanchipuram, Tamil Nadu, India.
S. Dorian Hanniel Terrence, Senior Resident, Department of Surgical Oncology, Govt. Arignar Anna Memorial Cancer Hospital and Research Institute, Karapettai, Kanchipuram, Tamil Nadu, India.
Senior Resident, Department of Surgical Oncology, Govt. Arignar Anna Memorial Cancer Hospital and Research Institute, Karapettai, Kanchipuram, Tamil Nadu, India.
Sasikala Kathiresan, Assistant Professor Department of Obstetrics and Gynecology, AIIMS, Madurai, Tamil Nadu, India.
Assistant Professor Department of Obstetrics and Gynecology, AIIMS, Madurai, Tamil Nadu, India.
Emil Phinehas Mariantony, Assistant Professor, Department of General Surgery, AIIMS, Madurai, Tamil Nadu, India.
Assistant Professor, Department of General Surgery, AIIMS, Madurai, Tamil Nadu, India.
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