GLUT-2 and Plasma Insulin Concentrations in Women with and without GDM
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Abstract
Objective: To determine GLUT-2 and plasma insulin concentrations in women with and without gestational diabetes. Design: A prospective longitudinal cohort study of Mexicans. Subjects/Patients: included pregnant patients aged 18-45 years with normal pregnancy and gestational diabetes, with gestation>24 weeks. Methods: Sociodemographic characteristics, gestational risk factors, and baseline and final measurements of anthropometrics, glucose, insulin, lipid, and GLUT-2 were recorded. The Mann-Whitney U test was used, 95%CI and p≤0.05 were considered, SPSS software was used vs25, approved by the Ethics and Research Committee (code: 2022-08-799). Results: A sample of 33 participants was analysed, 76.5% comprised the control group and 23.5% the GDM group, baseline and final clinical characteristics of the participants increased in the gestational diabetes group: GLUT-2 (28. 9±13.1 ng/mL vs 37.6±9.2 ng/mL, p=0.035) and insulin (33.8±11.1 µIU/mL vs 37.6±5.1 µIU/mL, p=0.017), both groups had hypercholesterolemia, and insulin resistance in the gestational diabetes group. Conclusion: The gestational diabetes group had higher GLUT-2 and insulin concentrations, as well as risk factors associated with pregnancy, suggesting that GLUT-2 measurement represents an alternative for better metabolic control and prevention of the development of this pathology.
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Copyright (c) 2026 Dr. Betsy Sosa, Cristian F. Layton Tovar, Adriana Garduño Alanis, Hugo Mendieta Zerón
This work is licensed under a Creative Commons Attribution 4.0 International License.
Creative Commons License All articles published in Annals of Medicine and Medical Sciences are licensed under a Creative Commons Attribution 4.0 International License.
Dr. Betsy Sosa, Universidad Autónoma del Estado de México, Toluca, 50130, México. COMECYT - Laboratorio de Investigación Hospital Materno Perinatal “Mónica Pretelini Sáenz", México.
Universidad Autónoma del Estado de México, Toluca, 50130, México.
COMECYT - Laboratorio de Investigación Hospital Materno Perinatal “Mónica Pretelini Sáenz", México.
Adriana Garduño Alanis, Universidad Autónoma del Estado de México, Toluca, 50130, México. Centro de Investigaciones en Nutrición y Salud, Instituto Nacional de Salud Pública, Morelos 62100 México. Consejo Nacional de Humanidades, Ciencias y Tecnología, México.
Universidad Autónoma del Estado de México, Toluca, 50130, México.
Centro de Investigaciones en Nutrición y Salud, Instituto Nacional de Salud Pública, Morelos 62100 México.
Consejo Nacional de Humanidades, Ciencias y Tecnología, México.
Hugo Mendieta Zerón, Universidad Autónoma del Estado de México, Toluca, 50130, México. Hospital Materno Perinatal “Mónica Pretelini Sáenz", Toluca, 50130, México.
Universidad Autónoma del Estado de México, Toluca, 50130, México.
Hospital Materno Perinatal “Mónica Pretelini Sáenz", Toluca, 50130, México.
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