Role of Maternal Serum ɓHCG in Prediction of Early Onset Pre Eclampsia and It’s Correlation with Uterine Artery Doppler

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Prof. Shaily Agarwal, MS  1 , Dr Sulfiya Shakeel Siddiqui  2 , Prof. Renu Gupta, MS  3 , Prof. Neena Gupta 1, MS  4 , Dr. Divya Dwivedi, MS  5 , Dr. Ashok Kumar Verma, MD  6 , Dr. Deepak Anand, MD  7
Professor, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India. 1 , Junior Resident, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India. 2 , Professor & Head, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India. 3 , Professor, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India. 4 , Professor, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India. 5 , Professor, Department of Radiology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India. 6 , Associate Professor, Department of Community Medicine, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India. 7
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Published: 2025-07-21
DOI: 10.5281/
Keywords:
Gonadotropin preeclampsia normotensive Eclampsia ɓhcg.

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Abstract

Background: Hypertensive disorders during pregnancy remain amongst the most significant and intriguing unsolved problems in obstetrics. The study aims at testing the hypothesis that women with high Serum beta hCG levels and alternations in waveforms in uterine artery doppler in first and second trimester have high risk of developing pre eclampsia. Methods: Serum ɓ hCG estimation was done by Sandwich chemiluminescence immunoassay method. All uterine artery waveforms were obtained using ultrasound machine attached to a 3.5 MHz curvilinear transducer, with color and pulsed Doppler abilities. Results: The mean maternal Serum ɓ HCG level in non severe pre eclampsia in first and second trimester were 30517.5+-11076.2 and 48204.6+-12074.0 respectively and for severe pre eclampsia were 37213.4+-11968.4and 52549.5+-12074.0 respectively which were significantly greater than normotensive (25819.9+-10017.8 and 32617.8+-6759.0 respectively p value<0.001). The number of complications in preeclampsia group were more than normotensive once. Conclusion: Mean ɓHCG levels are higher in preeclampsia group as compared with normotensive and maternal and fetal complications associated. 

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Role of Maternal Serum ɓHCG in Prediction of Early Onset Pre Eclampsia and It’s Correlation with Uterine Artery Doppler. (2025). Annals of Medicine and Medical Sciences, 663-669. https://doi.org/10.5281/
Original Article

Copyright (c) 2025 Prof. Shaily Agarwal, MS, Dr Sulfiya Shakeel Siddiqui, Prof. Renu Gupta, MS, Prof. Neena Gupta 1, MS, Dr. Divya Dwivedi, MS, Dr. Ashok Kumar Verma, MD, Dr. Deepak Anand, MD

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Creative Commons License All articles published in Annals of Medicine and Medical Sciences are licensed under a Creative Commons Attribution 4.0 International License.

Prof. Shaily Agarwal, MS, Professor, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Professor, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Dr Sulfiya Shakeel Siddiqui, Junior Resident, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Junior Resident, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Prof. Renu Gupta, MS, Professor & Head, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Professor & Head, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Prof. Neena Gupta 1, MS, Professor, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Professor, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Dr. Divya Dwivedi, MS, Professor, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Professor, Department of Obstetrics and Gynaecology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Dr. Ashok Kumar Verma, MD, Professor, Department of Radiology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Professor, Department of Radiology, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Dr. Deepak Anand, MD, Associate Professor, Department of Community Medicine, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

Associate Professor, Department of Community Medicine, Ganesh Shanker Vidyarthi Memorial Medical College, Kanpur, Uttar Pradesh, India.

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